Announcing Open Access to Electrophysiology of the Neuron
of the Neuron" is an interactive tutorial that comes with a computer disk
for simulation of single neurons on a Macintosh or IBM-PC compatible computer.
It was available from Oxford University Press ISBN #
0-19-509167-1 (mac) and 0-19-
509111-6 (PC), and is now out of print. It was designed to be an adjunct to Neurobiology,
3rd edition by Gordon Shepherd, but can also be used as a stand alone
News, May 31, 2014. A modern version has been developed:
Updated cross-platform EOTN version
from Carlos Manuel Rodriguez
and Michael Markham at University of Oklahoma
News, October 31, 2008. We are pleased to announce, that
since the book is no longer in print, we will be distributing an
eVersion of the
and the windows and
the Macintosh Classic
(not OS X) versions of the software for free.
If you already have installed the commercial software that came with the book, you can download complimentary upgrades for Windows
and Macintosh versions of the
software that comes with the book Electrophysiology of the Neuron.
These have poweruser
that allow additional features, such as modifying the display, editing
the voltage-dependent models, etc.
Click the following link to download the Setup program that will upgrade a current windows version of EOTN
to the latest version, one that includes support for Windows
printers and clipboard!
How to enable POWERUSER features
The instructions are briefly indicated in the online help, under Overview.
In Windows 95/98/ME/2000/XP you need to change the shortcut properties.
Right click on the program icon, then select properties
Select "shortcut", then "target".
Put the word poweruser (after a space) at the end of the line where the
VCWIN.exe or CCWIN.EXE is indicated.
Click on OK
Macintosh PowerUser version:
You can also download Macintosh PowerUser versions of the two programs.
Please note: These versions will only work if you have the previous version
already loaded on your computer.
The download files are in BinHex 4.0 format. To install these programs
on your computer:
Download CCLAMP-SU and VCLAMP-SU now:
Super User version of Current Clamp simulation program. HTTP
Super User version of Vurrent Clamp simulation program. HTTP
Movies of Intracellular Recordings!
We have found that it is very useful to see the activity of real neurons
in order to get an intuitive feel for how neurons behave. Therefore, we
have included here some Windows AVI movie files (with sound) that you can
download and watch.
first movie illustrates a neuron similar to that simulated and illustrated
in Figure 21 of Electrophysiology of the Neuron. This neuron is a human
cortical pyramidal cell maintained in vitro.
The cortical pyramidal cell responds to a current pulse with the generation
of a train of action potentials, the frequency of which slows down over
time, a process known as spike frequency adaptation.
The second movie is the same neuron after the slow Ca2+-activated K+
current I-AHP is blocked with the local application of serotonin. Now the
neuron generates less spike frequency adaptation and a higher frequency
of neuronal discharge.
Neurons in different parts of the brain generate different patterns
of activity. For example, neurons in the Thalamus behave quite distinctly
from those in Cerebral Cortex.
a comparison with the above movies of a cortical pyramidal cell, download
and watch this movie of the two states of activity in a Thalamic
Relay Neuron (4.4 Megabytes). These two states of activity are similar
to those illustrated in Figures 23 and 24 of Electrophysiology of the Neuron.
In this section, we illustrate new simulations that can be run in Windows
versions directly from the WWW.
Just set up your browser so that "*.cc4" files will start up CCwin.exe
as a helper application, and "*.vc4" will start up VCwin.exe.
Here is a copy of a current
clamp demo that illustrates spike frequency accomodation, to show how
you can interface CCwin with WWW!
And here is a voltage
clamp demo to illustrate that the envelope of tail currents closely
follows the envelope of the T current.
Thank you for visiting the Electrophysiology of the Neuron Web Page!
Comments or Questions:
John Huguenard or David
John Huguenard / John.Huguenard@stanford.edu
Department of Neurology and Neurological Sciences Stanford University
School of Medicine Stanford, CA 94305-5300
David A. McCormick / David.McCormick@Yale.edu
Section of Neurobiology Yale University School of Medicine 333 Cedar
Street New Haven, CT 06510